By M. Chris. Clayton College of Natural Health.

The analysis showed that in terms of the turnover of the pharmacy study: return on assets ratio in 2015 buy proventil 100mcg amex. Accounts payable turnover period indicates the growth in accounts receivable by up to 172 buy 100 mcg proventil. The analysis showed that it is recommended to periodically review the prices established for similar products by other companies pharmacy sphere, in order to establish competitive prices for retail goods. The analysis showed that it is necessary to increase the turnover expansion of the retail network, namely the increase in the number of outlets. The analysis showed that it is necessary to carry out measures to improve information provision. In the process of financial and economic activity of the studied pharmacy one of the negative factors is the lack of strategic information you need: the lack of a database on the market. This policy is due to the fact that in the developed countries to the issue of assigning the status fit enough carefully. The drug provision of the population and medical institutions is one of the priorities of the social policy of any state at the present stage. Therefore, the aim of our research was: an analysis of the main indicators of the pharmacy operation. Analysis of Principles for the Treatment of state regulation of medicinal products in the domestic and foreign pharmaceutical legislation shows that the main component of the regulatory policy system is the licensing of pharmaceutical activity, pharmacy law, the pricing of medicines and reimbursement (compensation value). In general, the requirements for the implementation of the retail sale of medicinal products can be divided into: - Requirements for obtaining a special permit (license); - Requirements regarding the number of pharmacies for a certain number of the population; - Requirements for the owners; - The place and the sale procedure requirements drugs (eg in Denmark, Germany, the Netherlands, Norway and the United Kingdom is not some prescription drugs can be purchased not only in licensed pharmacies, but also in conventional retail stores, supermarkets or licensed pharmacy (drugstore); - requirements regarding the sale of pharmacy (pharmacy). Virtually every country in Europe is regulated by the issue number of pharmacies, their location and the requirements for holders. In the first phase of our research we have identified the primary indicators of pharmaceutical firm work. In our view, the study pharmacy, the figure was analyzed and planned in the first place. On average, the turnover increased by 7%, costs decreased by 3%, the imposition of trade decreased by 3. The analysis showed that 49% of the total cost goes to pay, 29% on social charges Article, all other expenses amounted to 22%. The analysis of dynamics of average study pharmaceutical firm costs for items of fixed costs has shown that most of the articles have increased slightly, while other expenses decreased. At the last stage of our research we calculated the main indicators studied pharmaceutical firm work. An analysis of these calculations showed that every year due to a decrease in the level of trade overlays profitability decreased to 0,8%, which is very low, but in 2015 the amount of profit by increasing turnover increased. We have found that trade study pharmacy during the analyzed period increased an average of 1,078 times (7. The analysis studied pharmaceutical firm allowed to confirm the constant growth of expenses. It was found that the largest share in the total expenditure of pharmaceutical firms serving the public are wage costs - 49. Currently, the organization of effective medical and pharmaceutical care of patients suffering from depressive disorder in Ukraine is of great socio-economic importance. The introduction of modern multimodal antidepressants into the treatment of patients with depressive disorders allows using them for a long time to achieve full recovery and supports the premorbidal level of social functioning. Innovative drug Vortioxytine corresponds to the important contemporary requirements which are put forward for the treatment of depression, has not only a high efficiency in relation to affective symptoms, but also unique properties to enhance cognitive functioning and, consequently, the quality of life of the patient. However, the application of new approaches is complicated by the problem of its high cost. To make the analyzes of "willingness-to-pay" in the organization of treatment of patients with depressive disorders in Ukraine. The object of the research was the survey data of psychiatrists (55 persons) and family members of patients with severe depression (75 people), which was conducted during 2015 in Zaporozhye. The questionnaire worked up for physicians consisted of two parts, in the first part it was necessary to specify personal data (age, place of work, position, work experience in the position, etc. The aim of the second unit was to establish the attitudes of respondents towards the "willingness-to- pay" at the expense from personal funds and rationality of the real cost of treatment with the drug Vortioxytine from the perspective of the health system as a whole. The purpose of questioning of other suffering from depressive disorders patients was to identify the "willingness-to-pay" opportunities by private funds (before that, the respondents indicated the average monthly income per 1 person in the family ), the rationality of the real costs for the treatment with the medicine Vortioxytine from the standpoint of the patient (indicating the cost of its implementation) and determining the maximum "willingness-to-pay" for the expense of personal budget and the rationality of the real costs from the position of health care organization. In the last decade, the results of pharmacoeconomic analysis is widely used in the health care system of the developed countries, while taking such management decisions as registration of medicinal products, development of forms and clinical guidelines (recommendations, standards of conducting patients), to draw up a restrictive list of medical technologies, whicn should to be paid from the expense budget or social insurance. The most valuable for the decision makers, are considered 205 the results of the analysis "cost-effectiveness" and "cost-utility". The analysis of "cost- benefit" remains quite attractive for economists in the field of health care organization because only it gives an indication of economic (monetary) benefit of the technologies contributing to the restoration, preservation or promotion of health. In addition, the results give us an insight into the preferences of the population (potential market) and at the same time can be used for economic justification of the use of medicines. Among others patients the proportion of responses to questions was higher than that among health care workers – to assess "willingness-to-pay" for the personal expense without knowing the cost of treatment with Vortioxytine could 91. After the respondents were informed about the cost of the treatment, to evaluate "willingness-to-pay" could only 79.

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Take steps to enable patient to emerge slowly from benzodi- azepine overdose to avoid withdrawal reaction order proventil 100mcg without a prescription. Clinically important drug interactions: Drugs that increase toxic- ity of flumazenil: mixed drug overdoses purchase proventil 100 mcg with visa, tricyclic antidepressant overdose. Editorial comments • Flumazenil does not reverse the amnesic effect of benzodi- azepine overdose. Accordingly, the physician should advise patient’s family or caregiver of the need to follow the patient carefully following recovery. Flumazenil should be used cautiously in outpatients and hospitalized patients because of the possibility that patients may have frequent benzodiazepines use or dependence. Mechanism of action: Inhibits elaboration of many of the media- tors of allergic inflammation, eg, leukotrienes and other products of the arachidonic acid cascade. Contraindications: Untreated fungal, bacterial, or viral infec- tions, ocular herpes simplex, septic ulcers, nasal surgery or trauma, untreated infections of nasal mucosa, hypersensitivity to corticosteroids. Warnings/precautions: Use with caution in patients with tuber- culosis of the respiratory tract (active or quiescent), exposure to measles or chicken pox. These should be individualized according to the dis- ease being treated and the response of the patient. This drug should not be used in large amounts or for prolonged periods during pregnancy. Contraindications: Hypersensitivity to corticosteroids, marked impaired circulation, occlusive dressing if primary skin infec- tion; monotherapy in primary bacterial infections (eg, impetigo, cellulitis, rosacea), ophthalmic use, plaque psoriasis (wide- spread). Warnings/precautions • Use with caution in patients with primary skin infection and in those receiving other immunosuppressant drugs. Advice to patient • Avoid long-term application to the following areas of the body: eyes, face, rectum, genitals, skinfolds. These are areas most susceptible to development of skin atrophy and decol- oration. Adverse reactions • Common: itching, burning, skin dryness, erythema, folliculi- tis, hypertrichosis, allergic contact dermatitis, skin maceration, secondary infection, striae, millaria, skin atrophy. Parameters to monitor • Signs of infection: increased pain, purulent exudate, erythema. Organisms most likely to pro- duce intercurrent infection include Candida, Mycobacterium, Toxoplasma, pneumocystis, Nocardi, Ameba. This condition may become clinically significant after 3–4 weeks of drug application. Patients using topical steroids over large areas of the body for prolonged periods are also at risk. Editorial comments: Only 5% strength is suggested for topical treatment of superficial basal cell carcinoma. Mechanism of action: Blocks methylation of deoxyuridylic acid by inhibiting thymidylate synthetase. Warnings/precautions • Use with caution in patients with kidney or liver disease, high- dose pelvic radiation or who are concomitantly using other neoplastic drugs, in particular alkylating agents. Advice to patient • Use two forms of birth control including hormonal and barrier methods. Adverse reactions • Common: dermatitis, alopecia (reversible), stomatitis, nausea, vomiting, diarrhea, anorexia, mucositis. Clinically important drug interactions: Allopurinol, cimetidine increase effects/toxicity of fluorouracil. Treat with peroxide, tea, top- ical anesthetics such as benzocaine, lidocaine or antifungal drug. Editorial comments • Fluorouracil is used alone or in combination with other modalities of treatment, eg, radiation therapy, surgery, other chemotherapeu- tic agents. Warnings/precautions • Use with caution in patients with the following conditions: diabetes mellitus, seizures, liver or kidney disease. Patients should wear a bracelet identifying the condition and possibility of developing hypoglycemia. Adverse reactions • Common: anorexia, body pain, nausea, insomnia, anxiety, tremor, dry mouth. Mechanism of action: Stimulates receptors in androgen-responsive organs, thereby promoting growth and development of male sex organs. Drug should be administered only by physician who is aware of possible adverse effects of drug on bone maturation. Contraindications: Hypersensitivity, males with carcinoma of the breast, known or suspected carcinoma of the prostate, seri- ous cardiac, renal, or hepatic decompensation. Editorial comments • This drug is listed without details in the Physician’s Desk Reference, 54th edition, 2000. Mechanism of action: Inhibits cyclooxygenase, resulting in inhi- bition of synthesis of prostaglandins and other inflammatory mediators. Mechanism of action: Prevents uptake of androgens and blocks nuclear binding of androgens in prostatic tissue. Warnings/precautions • Warn patient not to discontinue therapy without consulting with physician.

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